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Demonstrates gastrodin's protective effects on spinal cord injury through microglial modulation and neuronal survival, indicating potential therapeutic applications.
This study demonstrates that GAS confers multifaceted protection against SCI by modulating microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype and by directly inhibiting neuronal apoptosis, primarily through activation of the PI3K/AKT signaling pathway. These findings indicate that GAS holds significant potential as a therapeutic candidate for the treatment of SCI.
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Feng et al. (2026) studied this question.
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