The relatively low incidence of high-grade endometrial carcinoma (HGEC) poses a significant challenge as it limits the conduct of extensive prospective studies dedicated to identifying the best treatment approach. In most large-scale clinical investigations, HGEC cases are sparsely represented. As a result, the generalizations drawn from these studies may not accurately pertain to HGEC. Herein, we comprehensively review the surgical treatment strategies for HGEC, with a particular focus on the impact of temperature-based therapies, minimally invasive approaches, and molecular subtypes. Our aim is to provide a solid basis for the individualized diagnosis and management of patients afflicted with this condition.
Peng et al. (Thu,) studied this question.