Supratentorial Brain Lesions in Unconscious Patients Map to a Common Human Brain Circuit

Joshua Kahan; Rafael Vignoli Lippert; Bassam Al‐Fatly; Qi Shen; Vedant Kansara; Mohamad J. Alshikho; Batool Rizvi; Heather L. Shouel; Satoshi Egawa; Jerina Carmona; Lucie Kruger; You‐Lim Song; Ángela Velázquez; Alex J. Klein; Danielle Bass; Daniel Samano Martin del Campo; Ana Karen Bolanos Saavedra; Elizabeth Carroll; Vincent Perlbarg; Louis Puybasset; Shivani Ghoshal; S. Agarwal; David Roh; Soojin Park; E. Sander Connolly; Ayham Alkhachroum; Adam M. Brickman; Jan Claassen

doi:10.1002/ana.78224

Key Points

The research aims to identify common brain circuit patterns in patients with impaired consciousness.
Examined brain lesions in unconscious patients
Analyzed shared network involvement patterns
Infers mechanistic relevance for consciousness regulation
Identified a common pattern of distributed network involvement
Suggested potential targets for neuromodulatory therapies
Indicated possible mechanisms related to consciousness regulation

Implication

Analysis shows common brain circuit pattern in unconscious patients, suggesting targets for therapies.

Abstract

Patients with impaired consciousness shared a common pattern of distributed network involvement that we infer to be mechanistically relevant to the regulation of consciousness that may serve as promising targets of neuromodulatory therapies. ANN NEUROL 2026.

Discussion

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Cite This Study

Kahan et al. (2026) studied this question.

synapsesocial.com/papers/69d34eac9c07852e0af98429 https://doi.org/10.1002/ana.78224

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Supratentorial Brain Lesions in Unconscious Patients Map to a Common Human Brain Circuit

Key Points

Implication

Abstract

Discussion

Cite This Study

Supratentorial Brain Lesions in Unconscious Patients Map to a Common Human Brain Circuit

Key Points

Implication

Abstract

Discussion

Cite This Study

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