What question did this study set out to answer?

This research aims to examine the effects of age at menopause on the progression of multimorbidity and mortality.

April 6, 2026BJOG An International Journal of Obstetrics & Gynaecology0 citations

Age at Menopause and Trajectories of Multimorbidity Progression to Mortality: A Multi‐State Analysis of UK Biobank Data

MLMin LiHarbin Medical University TLTianming LiuUniversity of Georgia HZHaibo ZhouHarbin Medical University

Key Result

Earlier menopause is associated with an increased risk of multimorbidity and mortality, mainly affecting trajectories from health to FCD and from FCD to multimorbidity.

Key Points

This research aims to examine the effects of age at menopause on the progression of multimorbidity and mortality.
Analyzed data from the UK Biobank including participants' health records.
Applied multi-state analysis to investigate different health trajectories.
Assessed the relationship between age at menopause and risk of multimorbidity and mortality.
Earlier menopause is linked to a higher risk of developing multimorbidity.
Two distinct health trajectories identified: from health to frailty (FCD) and frailty to multimorbidity.
The findings suggest that age at menopause has significant implications for long-term health.

Structured PICO

Does earlier menopause increase the risk of multimorbidity and mortality?

Population

Women in the UK Biobank

Intervention

Earlier menopause

Outcome

Multimorbidity and mortalityhard clinical

Earlier menopause is associated with an increased risk of progressing to multimorbidity and mortality.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Earlier menopause was associated with an increased risk of multimorbidity and mortality, mainly affecting two trajectories, from health to FCD and FCD to multimorbidity.

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