Provides the first evidence of N1 and N2 neutrophil polarization in the myocardial infarct region, with N1 polarization potentially mediated by DAMPs.
N1/N2 neutrophil subsets in infarction are hypothesis-generating; extends heterogeneity concepts but leaves open human relevance.
This study is the first to identify the existence of N1 and N2 neutrophils in the infarct region and reveals that N1 polarization could be mediated by DAMPs.
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Ma et al. (2016) studied this question.
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