Key result
Age-related decline in NCKX4-mediated calcium clearance accelerates aortic remodeling and drives early vascular aging.
Design
Preclinical
Identifies calcium clearance as a therapeutic target for vascular ageing; hypothesis-generating and should not yet change clinical practice.
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Livia Rodrigues Costa (2026) studied this question. Age-related decline in NCKX4-mediated calcium clearance accelerates aortic remodelling and drives early vascular ageing.
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