Discovery of novel 2,4-diarylaminopyrimidine derivatives as FAK inhibitors with potent anti-cancer potency

Key Points

• The study aims to evaluate 2,4-diarylaminopyrimidine derivatives as FAK inhibitors for cancer treatment.
• Synthesis of novel compounds
• Testing selectivity against FAK
• Assessing antitumor activity
• Comparative analysis of lead candidate
• Compound D12 shows improved selectivity for FAK
• Demonstrates potent antitumor activity
• Represents a promising candidate for cancer therapy