Abstract Introduction This study aimed to assess the impact of a 10-session hand massage protocol on hand function, grip strength, pinch strength, pain threshold, and tactile sensory threshold in patients with early-stage, seropositive rheumatoid arthritis (RA) without radiographic damage or hand deformity. Methods This study was a randomized controlled clinical trial. Thirty female RA patients with a diagnosis time of less than two years, seropositive, with low disease activity/remission, and without active arthritis in their hands were included in the study. Participants were randomized 1:1 to intervention and control groups. The intervention group underwent 10 hand massage sessions over a two-week period, in addition to regular medical care. The control group received only regular medical care. All assessments were performed at baseline (T1) and at week 2 (T2). Outcome measures included hand grip strength, pinch strength, pain threshold (dolorimetry), tactile sensory threshold (Semmes-Weinstein monofilament test), Duruöz Hand Index (DHI), and patient global assessment (PGA). Results A total of 30 RA patients were included in the study (intervention group, n = 15; control group, n = 15). At baseline, no significant differences were observed between the groups in demographic, laboratory, or clinical characteristics ( p > 0.05). In the intervention group, significant improvements in hand grip strength and pinch force were observed at T2 compared with baseline ( p = 0.008 and p = 0.023, respectively). Median hand grip strength increased from 55 (40–75) to 65 (45–80) kg, and median pinch strength increased from 15 (6–18) to 16 (11–21) kg. No significant alterations were noted in these parameters within the control group ( p > 0.05). In the control group, median hand grip strength was 45 (25–80) kg at baseline and 45 (20–80) kg at week 2, while median pinch strength was 14 (6–18) kg at baseline and 14 (5–19) kg at week 2. In the intervention group, significant reductions in DHI and PGA scores were recorded at the end of therapy ( p = 0.005 and p = 0.001, respectively). No significant differences were noted in DHI and PGA levels in the control group ( p > 0.05). Moreover, median PGA scores were significantly lower in the intervention group than in the control group at T2 (4 2–5 vs. 5 3–6; p 0.05). Conclusion Hand massage interventions for patients with RA enhance grip strength, hand function, and overall patient evaluations. No effect on pain or tactile thresholds was observed. Further studies with larger sample sizes and longer follow-up periods are required to corroborate these findings.
Khojakulova et al. (2026) studied this question.