Severe aortic valve stenosis can progress in homozygous familial hypercholesterolemia despite normalization of lipid levels post-liver transplant.
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Aortic stenosis may progress in homozygous FH after liver transplant despite lipid normalization; leaves open need for adjunctive therapies or surveillance.
Early onset coronary artery disease and aortic calcifications are characteristic features of patients with homozygous familial hypercholesterolemia. Standard medical therapy includes dietary modification, pharmacotherapy, and lipoprotein apheresis to lower serum low-density lipoprotein cholesterol (LDL-C). Liver transplant is a surgical option for the treatment of homozygous familial hypercholesterolemia and can lead to normal cholesterol levels. Vascular calcifications are known to progress despite standard medical therapy and have been reported after liver transplant in the setting of rejection. We present the first report of progressive severe aortic valve stenosis in a patient despite liver transplant with normalization of lipid levels and no history of graft rejection.
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Greco et al. (2016) studied this question.
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