Why the study?
Do carotid baroreflex stimulation and renal denervation differently influence atrial electrophysiology despite comparable blood pressure and heart rate reductions?
Do carotid baroreflex stimulation and renal denervation differently influence atrial electrophysiology despite comparable blood pressure and heart rate reductions?
While both renal denervation and baroreflex stimulation reduce blood pressure and heart rate comparably, baroreflex stimulation increases atrial fibrillation inducibility through vagally mediated shortening of the atrial effective refractory period, whereas renal denervation does not.
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BRS effects on AF inducibility warrant monitoring in translational studies; leaves open differential atrial impacts versus RDN in humans.
RDN and BRS resulting in comparable blood pressure and heart rate reductions differently influence atrial electrophysiology. Vagally mediated shortening of AERP, resulting in increased AF-inducibility, was observed with BRS but not with RDN.
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Linz et al. (2013) studied this question.
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