Why the study?
Are MTHFR gene polymorphisms associated with stroke severity and recurrence in patients with NVAF and cardioembolic stroke?
Are MTHFR gene polymorphisms associated with stroke severity and recurrence in patients with NVAF and cardioembolic stroke?
MTHFR gene polymorphisms (C677T and A1298C) may serve as genetic markers for increased stroke severity, recurrence, and cardiovascular comorbidity burden in patients with NVAF-related cardioembolic stroke.
May flag higher-risk NVAF stroke patients; leaves open whether MTHFR genotyping aids stratification or prevention.
The results obtained in this study demonstrate that MTHFR gene polymorphisms have a high prevalence in an NVAF cardioembolic stroke population. Moreover, an association between C677T mutation and stroke severity was highlighted. The C677T mutation in patients with NVAF was correlated with a higher incidence of cardiovascular comorbidities (hypertension HTN, heart failure (HF), dyslipidemia, type II diabetes mellitus (T2DM) with high HbA1c and increased inflammatory state). The A1298CMTHFR gene mutation was associated with a higher incidence of previous lacunar stroke and stroke recurrence rate, while dyslipidemia was the main cardiovascular comorbidity in this category.
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Chita et al. (2020) studied this question.
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