Why the study?
Does the presence of recognized genetic mutations affect the pattern of myocardial fibrosis assessed by CMR with T1 mapping in patients with hypertrophic cardiomyopathy?
Population
Patients with hypertrophic cardiomyopathy (HCM)
Comparison
Contrast-enhanced cardiac magnetic resonance… vs HCM patients without recognized genetic mutations
Design
Cross-sectional
Authors
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Supports genotype-specific fibrosis patterns in HCM; hypothesis-generating and should not yet change practice.
Does the presence of recognized genetic mutations affect the pattern of myocardial fibrosis assessed by CMR with T1 mapping in patients with hypertrophic cardiomyopathy?
In patients with hypertrophic cardiomyopathy, the presence of genetic mutations is associated with a distinct fibrotic phenotype characterized by more regional but less diffuse myocardial fibrosis on CMR.
Ellims et al. (2014) studied this question.
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