Why the study?
Does aspirin plus esomeprazole prevent recurrent ulcer bleeding better than clopidogrel in patients with a history of aspirin-induced ulcer bleeding?
Does aspirin plus esomeprazole prevent recurrent ulcer bleeding better than clopidogrel in patients with a history of aspirin-induced ulcer bleeding?
In patients with prior aspirin-induced ulcer bleeding, aspirin plus esomeprazole is superior to clopidogrel for preventing recurrent bleeding, challenging current recommendations.
Supports aspirin plus esomeprazole over clopidogrel to prevent recurrent ulcer bleeding; challenges current recommendations.
Among patients with a history of aspirin-induced ulcer bleeding whose ulcers had healed before they received the study treatment, aspirin plus esomeprazole was superior to clopidogrel in the prevention of recurrent ulcer bleeding. Our finding does not support the current recommendation that patients with major gastrointestinal intolerance of aspirin be given clopidogrel.
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Chan et al. (2005) studied this question.
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