Why the study?
Are plasma MMP-9 levels associated with the risk of first-time coronary heart disease events in a community-based middle-aged population?
Are plasma MMP-9 levels associated with the risk of first-time coronary heart disease events in a community-based middle-aged population?
Plasma MMP-9 levels are an independent predictor of first-time coronary heart disease events in middle-aged individuals, contrasting with previous findings that used serum MMP-9.
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Should not yet change CHD risk assessment; leaves open incremental value of plasma MMP-9 beyond standard predictors.
Levels of plasma MMP-9 are independently associated with risk of first-time CHD events, regardless of adjustments. These results are in contrast to previous prospective population-based studies based on MMP-9 in serum. It is essential that more studies look at MMP-9 levels in plasma to further evaluate the association with first coronary events.
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Garvin et al. (2015) studied this question.
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