In healthy individuals with a family history of early-onset CAD, coronary plaque is predominantly noncalcified, highlighting the potential need for earlier primary prevention.
May inform earlier primary prevention in familial early CAD; hypothesis-generating and needs prospective validation.
The majority of coronary plaque was noncalcified, particularly in younger individuals. These findings support the importance of assessing family history and suggest that early primary prevention interventions may be warranted at younger ages in families with early onset coronary artery disease.
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Kral et al. (2014) studied this question.
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