What question did this study set out to answer?

To determine whether sex differences exist in human peripheral vascular responses to adrenergic receptor agonists and nonadrenergic vascular stimuli in vivo.

October 1, 1987Circulation ResearchOpen Access

Sex differences in peripheral vascular adrenergic receptors.

View Full Paper

Ask AI

Bookmark

Authors

RFRobert FreedmanRutgers, The State University of New Jersey SSS C SabharwalWayne State University NDN. DesaiPitzer College

Discussion

Member takes

Implication

Sex differences in adrenergic vascular reactivity observed; leaves open effects on disease risk or sex-specific therapy.

Key Points

To determine whether sex differences exist in human peripheral vascular responses to adrenergic receptor agonists and nonadrenergic vascular stimuli in vivo.
Infused adrenergic agonists (phenylephrine, clonidine, and isoproterenol) and nonadrenergic agents (nitroglycerin and digoxin) into the brachial arteries of healthy men and women while measuring finger blood flow.
Evaluated vascular responses to non-pharmacological and indirect stimuli, including reflex vasoconstriction, reactive hyperemia, and intra-arterial tyramine infusion.
Men exhibited significant dose-dependent vasoconstriction to phenylephrine and clonidine and dose-dependent vasodilation to isoproterenol, whereas women showed no significant dose-related response to any of these agonists.
Vascular responses did not differ by sex following nonadrenergic interventions (nitroglycerin, digoxin, reactive hyperemia) or following reflex vasoconstriction and tyramine administration.

Cite This Study

Freedman et al. (1987) studied this question.

synapsesocial.com/papers/69d56ceb75589c71d767cea2 https://doi.org/10.1161/01.res.61.4.581

View Full Paper

Ask AI

Bookmark

Sex differences in peripheral vascular adrenergic receptors.

Discussion

Member takes

Implication

Key Points

Cite This Study

Sex differences in peripheral vascular adrenergic receptors.

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider