Why the study?
What are the hemodynamic characteristics of long-term calcium channel blocker responders in patients with idiopathic pulmonary arterial hypertension?
What are the hemodynamic characteristics of long-term calcium channel blocker responders in patients with idiopathic pulmonary arterial hypertension?
Long-term responders to calcium channel blockers in IPAH are rare (<10%) but exhibit near-normal hemodynamics during acute vasodilator testing.
Acute testing may identify rare long-term CCB responders in IPAH; leaves open prospective validation of hemodynamic thresholds before wider adoption.
Long-term CCB responders represent <10% of IPAH patients evaluated in a pulmonary vascular referral center. During acute vasodilator testing, these patients showed significantly lower levels of both mean PAP and PVR, which reached near-normal values.
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Sitbon et al. (2005) studied this question.
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