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October 16, 2009Psychosomatic MedicineOpen Access

Comorbid Depression and Anxiety Symptoms as Predictors of Cardiovascular Events: Results From the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study

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Why the study?

Do comorbid depression and anxiety symptoms predict cardiovascular events in women with suspected myocardial ischemia?

Population

Women with suspected myocardial ischemia

Design

Cohort

Authors

TRThomas RutledgeUniversity of California, San DiegoSLSarah LinkeSan Francisco Department of Public HealthDKDavid S. KrantzCross-Cutting Cardiology

Discussion

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Implication

Depression-anxiety interactions may refine CVD prediction in women with suspected ischemia; leaves open whether combined screening improves outcomes.

Key Points

  • Determine whether the predictive value of depression symptoms for cardiovascular disease events is modified by comorbid anxiety severity in women with suspected myocardial ischemia.
  • Evaluated women with suspected myocardial ischemia participating in the Women's Ischemia Syndrome Evaluation (WISE) study.
  • Analyzed the relationship between baseline depression symptoms, comorbid anxiety severity, and subsequent cardiovascular disease events.
  • The value of depression symptoms in predicting cardiovascular events varied according to the severity of comorbid anxiety.
  • Assessing depression symptoms alongside anxiety measures improved the clinical utility and accuracy of cardiovascular risk prediction.

Structured PICO

Do comorbid depression and anxiety symptoms predict cardiovascular events in women with suspected myocardial ischemia?

P
Population
Women with suspected myocardial ischemia
I
Intervention
Assessment of depression and anxiety symptoms
O
Outcome
Cardiovascular (CVD) eventshard clinical

The clinical utility of depression measures for predicting cardiovascular events in women with suspected ischemia may be improved by combining them with anxiety measures.

Cite This Study

Rutledge et al. (2009) studied this question.

synapsesocial.com/papers/69d56d3675589c71d767d005https://doi.org/10.1097/psy.0b013e3181bd6062

Topics

Women and heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gender Differences in the Noninvasive Evaluation and Management of Patients with Suspected Coronary Artery Disease1994 · 353 citations
  2. 2Lifetime Major Depression is Associated With Coronary Heart Disease in Older Adults: Results From the National Epidemiologic Survey on Alcohol and Related Conditions2007 · 43 citations
  3. 3ANXIETY, DEPRESSION, AND HEART RATE VARIABILITY2000 · 41 citations
  4. 4Cost and Cost-effectiveness of an Early Invasive vs Conservative Strategy for the Treatment of Unstable Angina and Non–ST-Segment Elevation Myocardial Infarction2002 · 136 citations
  5. 5Depression and Anxiety as Predictors of 2-Year Cardiac Events in Patients With Stable Coronary Artery Disease2008 · 577 citations