What question did this study set out to answer?

To determine the molecular mechanisms by which obesity-induced endoplasmic reticulum stress disrupts insulin action and contributes to type 2 diabetes.

October 14, 2004Science

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

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Authors

UÖUmut ÖzcanGazi University QCQiong CaoAmgen (United States)EYErkan YılmazAnkara University

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Implication

Preclinical study reveals that endoplasmic reticulum stress impairs insulin receptor signaling in obese mouse models, highlighting novel therapeutic targets for type 2 diabetes.

Key Points

To determine the molecular mechanisms by which obesity-induced endoplasmic reticulum stress disrupts insulin action and contributes to type 2 diabetes.
Examined endoplasmic reticulum (ER) stress and insulin receptor signaling cascades in cell culture and obese mouse models.
Evaluated peripheral insulin resistance in mice deficient in X-box-binding protein-1 (XBP-1), a key transcription factor regulating the ER stress response.
Obesity triggered ER stress, which suppressed insulin receptor signaling via hyperactivation of c-Jun N-terminal kinase (JNK) and subsequent serine phosphorylation of insulin receptor substrate-1 (IRS-1).
Deficiency in XBP-1 exacerbated cellular ER stress and directly induced insulin resistance in mice.

Cite This Study

Özcan et al. (2004) studied this question.

synapsesocial.com/papers/69d56dc075589c71d767d02f https://doi.org/10.1126/science.1103160

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Implication

Preclinical study reveals that endoplasmic reticulum stress impairs insulin receptor signaling in obese mouse models, highlighting novel therapeutic targets for type 2 diabetes.

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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