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June 15, 2004CirculationOpen Access

Atherogenic Lipoprotein Particles in Atherosclerosis

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Authors

RCRafael CarmenaPDPatrick DuriezJFJean‐Charles Fruchart

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Overview

Review uncovers diverse atherogenic lipoprotein particles driving cardiovascular risk beyond standard low-density lipoprotein, highlighting potential targets for precision coronary disease therapies.

Key Points

  • To review the roles of heterogeneous low-density lipoprotein particles, non-LDL lipoproteins, and apolipoprotein B-containing particles in the development and progression of atherosclerosis.
  • Narrative synthesis evaluating clinical and mechanistic evidence on LDL particle heterogeneity, triglyceride-rich lipoproteins, and non-LDL lipid subfractions in cardiovascular disease pathogenesis.
  • Apolipoprotein B-containing particles—including small, dense LDL, oxidized LDL, very-low-density lipoprotein, and intermediate-density lipoprotein—actively drive atherogenesis through diverse lipid and protein compositions.
  • Elevated plasma triglyceride concentrations independently associate with an increased risk of acute coronary events.
  • Lipoprotein(a) represents a significant, independent risk factor for atherosclerotic cardiovascular disease in both men and women.

Cite This Study

Carmena et al. (2004) studied this question.

synapsesocial.com/papers/69d56dc075589c71d767d030https://doi.org/10.1161/01.cir.0000131511.50734.44
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Also Consider

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  1. 1Hypertriglyceridemic HyperapoB: The Unappreciated Atherogenic Dyslipoproteinemia in Type 2 Diabetes Mellitus2001 · 336 citations
  2. 2Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.1989 · 1,894 citations
  3. 3LDL Particle Size Distribution Is Associated With Carotid Intima-Media Thickness in Healthy 50-Year-Old Men1999 · 105 citations
  4. 4Low-Density Lipoprotein Particle Concentration and Size as Determined by Nuclear Magnetic Resonance Spectroscopy as Predictors of Cardiovascular Disease in Women2002 · 412 citations
  5. 5Quantification of cholesterol in all lipoprotein classes by the VAP-II method.1994 · 136 citations