Adenosine deaminase for diagnosis of tuberculous pleural effusion: A systematic review and meta-analysis

Figures

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  Fig 1. Study selection process.

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  Fig 2. Forest plot of 174 studies on sensitivity and specificity of pleural fluid adenosine deaminase in diagnosing tuberculous pleural effusion. Solid squares indicate individual study estimates, and horizontal lines represent corresponding 95% confidence limits. Vertical dashed lines correspond to summary estimates of sensitivity and specificity.

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  Fig 3. Hierarchical summary receiver operating characteristic (HSROC) curves summarizing diagnostic performance of pleural fluid adenosine deaminase for diagnosis of tuberculous pleural effusion. Each individual study is represented by an open circle, whose size is proportional to the inverse standard error of sensitivity and specificity. The dark square represents the summary estimate of test accuracy, with the surrounding dashed zone outline denoting the 95% confidence region around this estimate.