Whole-Exome Sequencing Characterizes the Landscape of Somatic Mutations and Copy Number Alterations in Adrenocortical Carcinoma

C. Christofer Juhlin; Gerald Goh; James M. Healy; Annabelle L. Fonseca; Ute I. Scholl; Adam Stenman; John W. Kunstman; T Brown; John D. Overton; Shrikant Mane; Carol Nelson‐Williams; Martin Bäckdahl; Anna‐Carinna Suttorp; Matthias Haase; Murim Choi; Joseph Schlessinger; David L. Rimm; Anders Höög; Manju L. Prasad; Reju Korah; Catharina Larsson; Richard P. Lifton; Tobias Carling

doi:10.1210/jc.2014-3282

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Abstract

These findings highlight the importance of Wnt pathway dysregulation in ACC and corroborate the finding of homozygous deletion of Wnt repressors ZNRF3 and KREMEN1. Overall, mutations in either TP53 or CTNNB1 as well as focal CNAs at the ZNRF3 or TERT loci denote mutually exclusive events, suggesting separate mechanisms underlying the development of these tumors.

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Juhlin et al. (2014) studied this question.

synapsesocial.com/papers/69d56dd775589c71d767d119 https://doi.org/10.1210/jc.2014-3282

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Whole-Exome Sequencing Characterizes the Landscape of Somatic Mutations and Copy Number Alterations in Adrenocortical Carcinoma

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Whole-Exome Sequencing Characterizes the Landscape of Somatic Mutations and Copy Number Alterations in Adrenocortical Carcinoma

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