Fibrotic remodeling of subepicardial adipose tissue, potentially mediated by cytotoxic lymphocytes, may contribute to the structural substrate for atrial fibrillation.
May identify novel AF substrate in subepicardial fat; hypothesis-generating in animals, requiring human confirmation.
Atrial fibrillation is associated with the fibrosis of subepicardial fatty infiltrates, a process in which cytotoxic lymphocytes might be involved. This remodelling of the atrial subepicardium could contribute to structural remodelling forming a substrate for AF.
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Haemers et al. (2015) studied this question.
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