Doxorubicin-induced cardiotoxicity is mediated by impaired lysosomal acidification and blocked autophagic flux, suggesting that reducing autophagy initiation may offer a protective strategy.
Doxorubicin blocks autophagic flux in cardiomyocytes by impairing lysosome acidification and lysosomal function. Reducing autophagy initiation protects against doxorubicin cardiotoxicity.
Li et al. (Wed,) studied this question.