Doxorubicin-induced cardiotoxicity is mediated by impaired lysosomal acidification and blocked autophagic flux, suggesting that reducing autophagy initiation may offer a protective strategy.
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May support autophagy modulation to limit doxorubicin cardiotoxicity; hypothesis-generating in animal models, requiring human validation.
Doxorubicin blocks autophagic flux in cardiomyocytes by impairing lysosome acidification and lysosomal function. Reducing autophagy initiation protects against doxorubicin cardiotoxicity.
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Li et al. (2016) studied this question.
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