Key result
Remodeling of INa and ICaL alters refractory periods to stabilize ventricular tachycardia reentry.
Why the study?
Differences in INa and ICaL properties in cells from the center and outer pathways of a reentrant circuit during ventricular tachycardia and their impact on effective refractory periods and reentry stabilization were unclear.
Electrophysiological remodeling of sodium and calcium currents in different regions of a ventricular tachycardia circuit alters refractory periods in a way that stabilizes reentry.
Stabilizes reentry via ERP changes in animal VT circuits; hypothesis-generating, clinical translation unknown.
Despite differences in INa and ICaL properties in cells of the center and outer pathways of a reentrant circuit, the resulting changes in effective refractory periods tend to stabilize reentry in this remodeled substrate.
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Baba et al. (2005) studied this question. Cellular remodeling of INa and ICaL properties in a reentrant circuit alters effective refractory periods to stabilize reentry during ventricular tachycardia.
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