Electrophysiological remodeling of sodium and calcium currents in different regions of a ventricular tachycardia circuit alters refractory periods in a way that stabilizes reentry.
Despite differences in INa and ICaL properties in cells of the center and outer pathways of a reentrant circuit, the resulting changes in effective refractory periods tend to stabilize reentry in this remodeled substrate.
Baba et al. (Tue,) studied this question.