August 24, 2004
Regression of Hypertensive Left Ventricular Hypertrophy by Losartan Compared With Atenolol
Structured PICO
Does losartan improve LVH regression in hypertensive patients with ECG LVH compared to atenolol?
P
Population
Hypertensive patients with ECG left ventricular hypertrophy (LVH)
I
Intervention
Losartan, plus hydrochlorothiazide and other medications when needed for pressure control
C
Comparator
Conventional atenolol-based treatment
O
Outcome
Left ventricular hypertrophy (LVH) regressionsurrogate
Losartan-based antihypertensive therapy demonstrates superior efficacy over atenolol for reversing left ventricular hypertrophy, a key marker of hypertensive target organ damage.
Abstract
Antihypertensive treatment with losartan, plus hydrochlorothiazide and other medications when needed for pressure control, resulted in greater LVH regression in patients with ECG LVH than conventional atenolol-based treatment. Thus, angiotensin receptor antagonism by losartan has superior efficacy for reversing LVH, a cardinal manifestation of hypertensive target organ damage.
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Authors
Richard B. Devereux
Cardiac Imaging
Björn Dahlöf
Preventive Cardiology
E
Eva Gerdts
Preventive Cardiology
Journals
Circulation
Actions
Institutions
Helsinki University Hospital
United States Department of Veterans Affairs
Haukeland University Hospital
References and Citations
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