Does losartan improve LVH regression in hypertensive patients with ECG LVH compared to atenolol?
Losartan-based antihypertensive therapy demonstrates superior efficacy over atenolol for reversing left ventricular hypertrophy, a key marker of hypertensive target organ damage.
Antihypertensive treatment with losartan, plus hydrochlorothiazide and other medications when needed for pressure control, resulted in greater LVH regression in patients with ECG LVH than conventional atenolol-based treatment. Thus, angiotensin receptor antagonism by losartan has superior efficacy for reversing LVH, a cardinal manifestation of hypertensive target organ damage.
Devereux et al. (2004) studied this question.