Live-cell STED nanoscopy demonstrates that early heart failure development after myocardial infarction is characterized by proliferative T-tubule membrane changes, network fracturing, and excitation-contraction uncoupling.
Animal models reveal early post-MI membrane remodeling; leaves open whether T-tubule stabilization alters human HF progression.
This study introduces STED nanoscopy for live mapping of TT membrane structures. During early HF development, the local TT morphology and associated proteins were significantly altered, leading to differential network remodeling and Ca(2+) release dyssynchrony. Our data suggest that TT remodeling during HF development involves proliferative membrane changes, early excitation-contraction uncoupling, and network fracturing.
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Wagner et al. (2012) studied this question.
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