Epicardial adipose tissue in patients with cardiovascular disease exhibits a pathogenic mRNA profile, suggesting local chronic inflammation contributes to the pathogenesis of coronary artery disease.
Epicardial and omental fat exhibit a broadly comparable pathogenic mRNA profile, this may arise in part from macrophage infiltration into the epicardial fat. This study highlights that chronic inflammation occurs locally as well as systemically potentially contributing further to the pathogenesis of coronary artery disease.
Baker et al. (Fri,) studied this question.