Apamin-sensitive calcium-activated potassium currents are upregulated in rabbit ventricles with chronic myocardial infarction, playing a significant role in repolarization during tachycardia.
Hypothesis-generating for IKAS-targeted therapy post-MI; requires human validation before clinical consideration.
We conclude that IKAS is increased in MI ventricles and contributes significantly to ventricular repolarization especially during tachycardia.
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Lee et al. (2013) studied this question.
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