Does targeting a higher mean arterial pressure (80 to 85 mm Hg) reduce mortality compared to a lower target (65 to 70 mm Hg) in patients with septic shock undergoing resuscitation?
Targeting a higher mean arterial pressure (80-85 mm Hg) does not improve 28-day or 90-day mortality compared to a standard target (65-70 mm Hg) in patients with septic shock.
Targeting a mean arterial pressure of 80 to 85 mm Hg, as compared with 65 to 70 mm Hg, in patients with septic shock undergoing resuscitation did not result in significant differences in mortality at either 28 or 90 days. (Funded by the French Ministry of Health; SEPSISPAM ClinicalTrials.gov number, NCT01149278.).
Asfar et al. (2014) studied this question.