Does low dose (1.25 mg) ramipril once daily improve cardiovascular and renal outcomes in patients with type 2 diabetes and albuminuria?
Low-dose ramipril (1.25 mg/day) does not provide the cardiovascular and renal benefits observed with higher doses (10 mg/day) in patients with type 2 diabetes and albuminuria.
Low dose (1.25 mg) ramipril once daily has no effect on cardiovascular and renal outcomes of patients with type 2 diabetes and albuminuria, despite a slight decrease in blood pressure and urinary albumin. The cardiovascular benefits of a daily higher dose (10 mg) ramipril observed elsewhere are not found with an eightfold lower daily dose.
Marre et al. (Wed,) studied this question.