March 13, 2000Archives of Internal Medicine
Angiotensin-Converting Enzyme Inhibitor–Associated Elevations in Serum Creatinine
Why the study?
Does an acute increase in serum creatinine of up to 30% after ACE inhibitor initiation predict long-term preservation of renal function?
Population
Patients initiating ACE inhibitor therapy, including those with baseline creatinine >124 pmol/L (>1.4 mg/dL)
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
May support continuing ACE inhibitors with ≤30% creatinine rises; leaves open prospective confirmation.
Structured PICO
Does an acute increase in serum creatinine of up to 30% after ACE inhibitor initiation predict long-term preservation of renal function?
P
Population
Patients initiating ACE inhibitor therapy, including those with baseline creatinine >124 pmol/L (>1.4 mg/dL)
I
Intervention
ACE inhibitor therapy
O
Outcome
Long-term preservation of renal functionsurrogate
An acute rise in serum creatinine of up to 30% after starting an ACE inhibitor is associated with long-term renal preservation and should not prompt drug withdrawal unless it exceeds 30% or hyperkalemia develops.
Cite This Study
Bakris et al. (2000) studied this question.