Comparison of Thrombolysis Followed by Broad Use of Percutaneous Coronary Intervention With Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Acute Myocardial Infarction

Nicolas Danchin; Pierre Coste; Jean Ferrières; Philippe Gabríel Steg; Yves Cottin; Didier Blanchard; Loïc Belle; Bernard Ritz; Gilbert Kirkorian; Michael Angioi; Philippe Sans; Bernard Charbonnier; Hélène Eltchaninoff; Pascal Guéret; Khalifé Khalifé; Philippe Asseman; J. Puel; Patrick Goldstein; Jean-Pierre Cambou; Tabassome Simon

doi:10.1161/circulationaha.107.762765

Why the study?

Does a pharmacoinvasive strategy combining thrombolysis and liberal PCI yield comparable survival rates to primary PCI in patients with STEMI?

Key Points

To compare short- and long-term survival outcomes between early thrombolysis combined with percutaneous coronary intervention and standard primary percutaneous coronary intervention in acute myocardial infarction.
Evaluated a pharmacoinvasive strategy coupling early thrombolysis after symptom onset with liberal percutaneous coronary intervention (PCI).
Compared survival outcomes of this pharmacoinvasive regimen directly against primary percutaneous coronary intervention (PPCI).
Early survival following prompt treatment matched primary PCI outcomes, preserving short-term clinical efficacy when initiated early after symptom onset (exact numerical values not reported).
One-year survival outcomes remained equivalent between the pharmacoinvasive strategy and primary percutaneous intervention (exact numerical values not reported).

Structured PICO

Does a pharmacoinvasive strategy combining thrombolysis and liberal PCI yield comparable survival rates to primary PCI in patients with STEMI?

P

Population

Patients with ST-Segment-Elevation Acute Myocardial Infarction (STEMI) treated early after symptom onset

I

Intervention

Pharmacoinvasive strategy combining thrombolysis with liberal use of percutaneous coronary intervention (PCI)

C

Comparator

Primary percutaneous coronary intervention (PPCI)

O

Outcome

Early and 1-year survival rateshard clinical

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Implication

A pharmacoinvasive strategy combining thrombolysis with liberal PCI provides comparable early and 1-year survival to primary PCI for STEMI patients treated early.

Abstract

When used early after the onset of symptoms, a pharmacoinvasive strategy that combines thrombolysis with a liberal use of PCI yields early and 1-year survival rates that are comparable to those of PPCI.

Discussion

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Cite This Study

Danchin et al. (2008) studied this question.

synapsesocial.com/papers/69d5715775589c71d767e089 https://doi.org/10.1161/circulationaha.107.762765

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Comparison of Thrombolysis Followed by Broad Use of Percutaneous Coronary Intervention With Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Acute Myocardial Infarction

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Comparison of Thrombolysis Followed by Broad Use of Percutaneous Coronary Intervention With Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Acute Myocardial Infarction

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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