Why the study?
Does aspirin therapy reduce cardiovascular events in women and men for primary prevention?
Does aspirin therapy reduce cardiovascular events in women and men for primary prevention?
In primary prevention, aspirin reduces cardiovascular events with sex-specific benefits (ischemic stroke in women, MI in men) but significantly increases bleeding risk in both sexes.
Supports individualized aspirin in primary prevention after bleeding risk assessment; confirms sex-specific ischemic benefits in men and women.
For women and men, aspirin therapy reduced the risk of a composite of cardiovascular events due to its effect on reducing the risk of ischemic stroke in women and MI in men. Aspirin significantly increased the risk of bleeding to a similar degree among women and men.
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Berger et al. (2006) studied this question.
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