Uraemic adipose tissue in advanced CKD exhibits increased pro-inflammatory gene expression, potentially impacting the uraemic phenotype.
Raises possibility of adipose-targeted therapies in advanced CKD; hypothesis-generating pending interventional trials.
These gene expression differences suggest that inflammatory and oxidative stress activities may be important features of the intrinsic properties of uraemic adipose tissue, which may have significant effects on the uraemic phenotype.
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Witasp et al. (2010) studied this question.
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