December 6, 2005
The G Protein–Gated Potassium CurrentIK,AChIs Constitutively Active in Patients With Chronic Atrial Fibrillation
Structured PICO
P
Population
Patients with chronic atrial fibrillation (cAF)
O
Outcome
Basal inward rectifier K+ current activitysurrogate
Constitutively active I(K,ACh) contributes to larger basal inward rectifier K+ currents in chronic atrial fibrillation, identifying it as a potential novel therapeutic target.
Abstract
Our results demonstrate that larger basal inward rectifier K+ current in cAF consists of increased IK1 activity and constitutively active I(K,ACh). Blockade of I(K,ACh) may represent a new therapeutic target in AF.
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Cite this study
Dobrev et al. (Tue,) studied this question.
synapsesocial.com/papers/69d5717075589c71d767e1de — DOI: https://doi.org/10.1161/circulationaha.105.575332
Authors
Dobromir Dobrev
Electrophysiology
A
Adina Friedrich
University of Szeged
N
Niels Voigt
Electrophysiology
Journals
Circulation
Actions
Institutions
University of Szeged
References and Citations
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