Why the study?
Does high-sensitivity cardiac troponin T testing using 0 and 3 h blood draws accurately diagnose myocardial infarction in patients presenting to the emergency department?
Does high-sensitivity cardiac troponin T testing using 0 and 3 h blood draws accurately diagnose myocardial infarction in patients presenting to the emergency department?
The Elecsys Troponin T Gen 5 STAT test provides high sensitivity (>94%) and negative predictive value (≥99%) for rapid diagnosis of MI in the ED using 0 and 3 hour blood draws.
Supports hs-cTnT 0/3-h rule-out in ED; low-certainty evidence leaves hospitalization impact open.
The Elecsys Troponin T Gen 5 STAT test (distributed in the United States (US) by Roche Diagnostics, Indianapolis, IN) is the first high-sensitivity cardiac troponin test approved for use by the FDA in the US (2017). Areas covered: The test offers clinicians the opportunity for more rapid decision-making for diagnosing myocardial infarction (MI) in the emergency department (ED). The Troponin T Gen 5 STAT test (labeled as TNT-G5ST on the reagent pack) is similar to the Troponin T hs STAT (TNT-HSST) and Troponin T hs (TNT-HS) tests that have been available outside the US since 2009. Collectively, these tests can all be considered as high-sensitivity cardiac troponin T (hs-cTnT) assays. Expert commentary: Studies performed in the US and throughout the world using 0 and 3 h blood draws for hs-cTnT testing in patients with possible MI have reliably achieved a sensitivity of >94% and negative predictive value of ≥99% for MI in the ED setting.
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Kavsak et al. (2018) studied this question.
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