Characterization of Conduction in the Ventricles of Normal and Heterozygous Cx43 Knockout Mice Using Optical Mapping

Gregory E. Morley; Dhananjay Vaidya; Faramarz H. Samie; Cecilia Lo; Mario Delmar; José Jalife

doi:10.1111/j.1540-8167.1999.tb00192.x

October 1, 1999Journal of Cardiovascular Electrophysiology

Characterization of Conduction in the Ventricles of Normal and Heterozygous Cx43 Knockout Mice Using Optical Mapping

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Key Points

To evaluate local ventricular conduction velocity and overall electrical propagation in wild-type versus heterozygous connexin 43 knockout (Cx43+/-) mice.
Applied a sensitive optical mapping method to accurately record local conduction velocities across mouse ventricles.
Compared electrophysiological measurements and standard electrocardiogram (ECG) parameters between wild-type and heterozygous Cx43 knockout (Cx43+/-) mice.
Local ventricular conduction velocities showed no detectable changes in heterozygous Cx43 knockout mice compared to wild-type controls.
Surface electrocardiogram (ECG) parameters in Cx43+/- mice remained equivalent to baseline values recorded in wild-type mice.

Structured PICO

P

Population

Normal (wild-type) and heterozygous Cx43 knockout (Cx43+/-) mice

C

Comparator

Wild-type mice

O

Outcome

Local conduction velocities (CVs) throughout the ventricles and ECG parameter valuessurrogate

Heterozygous knockout of Cx43 does not alter ventricular conduction velocities or ECG parameters in mice.

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Implication

Does not support Cx43 haploinsufficiency causing conduction slowing in mice; leaves open its role in human arrhythmogenesis.

Abstract

A sensitive method that accurately measures local CVs throughout the ventricles revealed no changes in Cx43+/- mice, which is consistent with the demonstration that ECG parameter values in the heterozygous mice are the same as those in wild-type mice.

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Cite This Study

Morley et al. (1999) studied this question.

synapsesocial.com/papers/69d5717f75589c71d767e26d https://doi.org/10.1111/j.1540-8167.1999.tb00192.x

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Characterization of Conduction in the Ventricles of Normal and Heterozygous Cx43 Knockout Mice Using Optical Mapping

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Characterization of Conduction in the Ventricles of Normal and Heterozygous Cx43 Knockout Mice Using Optical Mapping

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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