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October 1, 1999Journal of Cardiovascular Electrophysiology269 citations

Characterization of Conduction in the Ventricles of Normal and Heterozygous Cx43 Knockout Mice Using Optical Mapping

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GMGregory E. MorleyDVDhananjay VaidyaFSFaramarz H. Samie

Key Points

  • To evaluate local ventricular conduction velocity and overall electrical propagation in wild-type versus heterozygous connexin 43 knockout (Cx43+/-) mice.
  • Applied a sensitive optical mapping method to accurately record local conduction velocities across mouse ventricles.

Structured PICO

P
Population
Normal (wild-type) and heterozygous Cx43 knockout (Cx43+/-) mice
C
Comparator
Wild-type mice
O
Outcome
Local conduction velocities (CVs) throughout the ventricles and ECG parameter valuessurrogate

Heterozygous knockout of Cx43 does not alter ventricular conduction velocities or ECG parameters in mice.

Abstract

A sensitive method that accurately measures local CVs throughout the ventricles revealed no changes in Cx43+/- mice, which is consistent with the demonstration that ECG parameter values in the heterozygous mice are the same as those in wild-type mice.

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Cite This Study

Morley et al. (1999) studied this question.

synapsesocial.com/papers/69d5717f75589c71d767e26dhttps://doi.org/10.1111/j.1540-8167.1999.tb00192.x
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