Key result
Heterotopic ossification is common in end-stage valvular disease, potentially driven by microfracture repair.
Why the study?
Heterotopic ossification with mature lamellar bone formation and active remodeling is a relatively common and unexpected finding in end-stage valvular heart disease and may relate to repair of pathological microfractures in calcified valves.
Heterotopic ossification is a common finding in end-stage valvular heart disease, potentially linked to the repair of microfractures in calcified valves.
Hypothesis-generating for mechanisms of valvular calcification; should not change practice without prospective data.
Heterotopic ossification consisting of mature lamellar bone formation and active bone remodeling is a relatively common and unexpected finding in end-stage valvular heart disease and may be associated with repair of pathological microfractures in calcified cardiac valves.
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Mohler et al. (2001) studied this question. Heterotopic ossification is a relatively common finding in end-stage valvular heart disease and may be associated with the repair of pathological microfractures in calcified cardiac valves.
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