Heterotopic ossification is a common finding in end-stage valvular heart disease, potentially linked to the repair of microfractures in calcified valves.
Heterotopic ossification consisting of mature lamellar bone formation and active bone remodeling is a relatively common and unexpected finding in end-stage valvular heart disease and may be associated with repair of pathological microfractures in calcified cardiac valves.
Mohler et al. (Tue,) studied this question.