A 69-year-old man with esophageal cancer underwent dual-tracer PET/CT using 18 F-FDG and 68 Ga-FAPI during his treatment. At baseline, neither scan showed abnormal uptake in the rectum. Three months later, an interim 18 F-FDG PET/CT revealed focal uptake in the rectum, while the 68 Ga-FAPI PET/CT showed no abnormal findings. Seventeen months later, he received a third dual-tracer PET/CT for surveillance. Both 18 F-FDG and 68 Ga-FAPI PET/CT detected abnormal activity in the same area of the rectum . The lesion was later confirmed as adenocarcinoma by histopathology after surgery. Our case demonstrated the 18 F-FDG PET/CT could identify the rectal malignancy before 68 Ga-FAPI PET/CT.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: