February 2, 2017Open Access

Myocardial Oxygen Consumption and Efficiency in Aortic Valve Stenosis Patients With and Without Heart Failure

PICO estructurado

Does myocardial external efficiency differ in aortic stenosis patients with reduced contractile function or paradoxical low-flow, low-gradient AS compared to those with preserved function?

Población

Patients with aortic valve stenosis (AS) with and without heart failure, including subgroups with left ventricular ejection fraction <50%, global longitudinal strain greater than -12%, or paradoxical low-flow, low-gradient AS.

Resultado

Myocardial oxygen consumption (MVO2) and myocardial external efficiency (MEE)surrogate

Reduced myocardial external efficiency in AS patients with reduced contractile function or paradoxical low-flow, low-gradient AS suggests mitochondrial uncoupling may contribute to their poor prognosis.

Resumen

AS patients display a persistent ability to maintain normal MVO2 and MEE (ie, the ability to convert energy into stroke work); however, patients with left ventricular ejection fraction <50%; global longitudinal strain greater than -12%; or paradoxical low-flow, low-gradient AS demonstrate reduced MEE. These findings suggest that mitochondrial uncoupling contributes to the dismal prognosis in patients with reduced contractile function or paradoxical low-flow, low-gradient AS.

Leer artículo completoexternamente

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Journals

Journal of the American Heart Association

SHILAP Revista de lepidopterología

Institutions

Aarhus University Hospital

Regional Hospital Horsens

References and Citations

Add This Paper to Your Research Feed

Any time a new paper drops it will be there.