SIRT1 represents a potential therapeutic target for preventing doxorubicin-induced cardiomyopathy by suppressing oxidative stress and p38MAPK-mediated apoptosis.
May identify SIRT1 as target against doxorubicin cardiomyopathy; animal data leave translation to patients open.
These results support the role of SIRT1 as an important regulator of cardiomyocyte apoptosis during doxorubicin-induced heart injury, which may represent a potential therapeutic target for doxorubicin-induced cardiomyopathy.
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Ruan et al. (2015) studied this question.
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