SIRT1 represents a potential therapeutic target for preventing doxorubicin-induced cardiomyopathy by suppressing oxidative stress and p38MAPK-mediated apoptosis.
These results support the role of SIRT1 as an important regulator of cardiomyocyte apoptosis during doxorubicin-induced heart injury, which may represent a potential therapeutic target for doxorubicin-induced cardiomyopathy.
Ruan et al. (Thu,) studied this question.