Does aerobic exercise training improve NO bioavailability and vascular relaxation in healthy femoral arteries?
Aerobic exercise training enhances vascular relaxation by increasing NO bioavailability through eNOS upregulation and miRNA downregulation.
The results of the present study provide a molecular basis for exercise-induced NO bioavailability in healthy femoral arteries. Increased caveolae domain and eNOS expression/activity in Tr arteries are associated with downregulation of miRNA-124a and -155, as well as are involved with higher antioxidant defense, subsequently inducing a favorable endothelium-dependent milieu in Tr arteries.
Paula et al. (Wed,) studied this question.