Recent Insights Into the Regulation of Coagulation and Thrombosis

Hemostatic clot formation is the result of a balance between the procoagulant system responding to tissue trauma and the anticoagulant system, which restricts clot formation to the injury site. Imbalances in coagulation lead to a tendency towards either thrombosis or bleeding. Over the past two years, studies published in Arteriosclerosis, Thrombosis, and Vascular Biology have provided insights into the regulation of this crucial system. Here, we highlight recent discoveries concerning the two pathways of thrombin formation, the extrinsic tissue factor (TF) pathway and the intrinsic contact pathway, and the contributions of platelet activation to the thrombotic process.