Tanshinone II-A sodium sulfonate (DS-201) enhances human BKCa channel activity specifically through the pore-forming α subunit, providing mechanistic insight into its pharmacological effects.
DS-201 selectively targets the pore-forming α subunit of human BKCa channels, thus enhancing the channel activities and increasing the subunit expression and trafficking, whereas the β1 subunit does not contribute to the action of DS-201.
Tan et al. (Mon,) studied this question.