The IL-6 family of cytokines mediates endothelin-1-induced expression of fetal genes in cardiac myocytes, providing insight into hypertrophic signaling pathways.
May implicate IL-6/gp130 in ET-1-driven myocyte hypertrophy; extends pathway insights but leaves clinical translation open.
We here examined the role of the interleukin-6 (IL-6) family of cytokines in endothelin-1 (ET-1)-induced hypertrophic responses using cultured cardiac myocytes of neonatal rats. ET-1 induced expression of IL-6 and leukemia inhibitory factor (LIF) genes. ET-1-induced LIF gene expression was abolished by inhibition of protein kinase C activity. ET-1 activated the promoter of atrial natriuretic peptide and beta-type myosin heavy chain genes through the tyrosine kinase pathway and IL-6 receptor gp130. These results suggest that the IL-6 family of cytokines mediates ET-1-induced expression of some fetal genes in cardiac myocytes.
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Saito et al. (1999) studied this question.
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