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January 5, 2015British Journal of PharmacologyOpen Access

Compound 21, a selective agonist of angiotensin AT₂ receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo

Amanda K. Sampson Jennifer C. Irvine Waled Shihata Dragana Dragoljevic Natalie Lumsden Olivier Huet Tyrone A. Barnes Thomas Unger U. Muscha Steckelings Garry Jennings Robert E. Widdop Jaye Chin‐Dusting

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Why the study?

Does Compound 21 prevent endothelial inflammation and leukocyte adhesion in vitro and in vivo?

Structured PICO

Does Compound 21 prevent endothelial inflammation and leukocyte adhesion in vitro and in vivo?

P

Population

in vitro and in vivo models of TNFα-induced and high-fat diet (HFD)-induced vascular inflammation

I

Intervention

Compound 21 (C21), a selective agonist of angiotensin AT2 receptors

O

Outcome

Endothelial inflammation and leukocyte adhesionsurrogate

Compound 21 demonstrates anti-atherosclerotic properties through AT2 receptor-mediated vascular anti-inflammatory effects in preclinical models.

Implication

Supports AT2 agonism for vascular anti-inflammation; hypothesis-generating and requires clinical trials before practice change.

Abstract

C21 prevented TNFα-induced and HFD-induced vascular inflammation in vitro and in vivo. Our data provide strong evidence that the anti-atherosclerotic actions of C21 were due to vascular anti-inflammatory effects, mediated by AT2 receptors.

Discussion

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Cite This Study

Sampson et al. (2015) studied this question.

synapsesocial.com/papers/69d573009d980f6498ccb244 https://doi.org/10.1111/bph.13063

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Compound 21 Induces Vasorelaxation via an Endothelium- and Angiotensin II Type 2 Receptor-Independent Mechanismpreclinical · 2012 · 59 citations
2AT <sub>2</sub> R (Angiotensin AT2 Receptor) Agonist, Compound 21, Prevents Abdominal Aortic Aneurysm Progression in the Ratpreclinical · 2018 · 31 citations
3The angiotensin AT2-receptor agonist compound 21 is an antagonist for the thromboxane TP-receptor – Implications for preclinical studies and future clinical usepreclinical · 2023 · 5 citations
4Angiotensin Type 2 Receptor Agonist Compound 21 Reduces Vascular Injury and Myocardial Fibrosis in Stroke-Prone Spontaneously Hypertensive Ratspreclinical · 2011 · 167 citations
5Direct Angiotensin II Type 2 Receptor Stimulation Acts Anti-Inflammatory Through Epoxyeicosatrienoic Acid and Inhibition of Nuclear Factor κBpreclinical · 2010 · 208 citations

More related papers

C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT2, Mas and B2 receptors2021
AT2R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet2021
AT <sub>2</sub> Receptor Activation Prevents Sodium Retention and Reduces Blood Pressure in Angiotensin II–Dependent Hypertension2016

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