Why the study?
Does cardiac-restricted overexpression of tumor necrosis factor cause atrial arrhythmias and structural remodeling in a transgenic mouse model?
Does cardiac-restricted overexpression of tumor necrosis factor cause atrial arrhythmias and structural remodeling in a transgenic mouse model?
Cardiac-restricted TNF overexpression in mice leads to downregulation of connexin40 and an increased prevalence of atrial arrhythmias, providing a mechanistic link between inflammation and atrial electrical remodeling.
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TNF-driven inflammation induces supraventricular arrhythmias in transgenic mice; leaves open applicability to human atrial fibrillation.
Sawaya et al. (2006) studied this question.
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