Daytime and outcomes after cardiac surgery: Systematic review and metaanalysis, insights from a large UK database review and post-hoc trial analysis

Figures

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  Fig. 1. Forrest plot of Odds Ratios of Myocardial Infarction in patients undergoing pm vs surgery t am surgery. Abbreviations: AVR- Aortic valve replacement; CABG – coronary artery by-pass grafting; PSM – propensity matched study; RCT – srandomised controlled trial.

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  Fig. 2. Forrest plot of Odds Ratios of 30-day mortality in patients undergoing pm vs am surgery. Abbreviations: AVR- Aortic valve replacement; CABG – coronary artery by-pass grafting; PSM – propensity matched study; RCT – srandomised controlled trial.

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  Fig. 3. Cardiac Troponin I release in the am vs pm surgery cohorts at the seven-time points (hours post-reperfusion). Data are summarised as mean±SEM.

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  Fig. 4. ATP/AMP (A), ATP/ADP (B) and cardiomyocytes energy charge (C) in the am and pm myocardial biopsies taken from left and right ventricle, pre-and post-reperfusion in 88patients undergoing AVR (N=23) or CABG (N=65). Data are summarised as mean±SEM. Abbreviations: Pre- LV: left ventricle biopsy pre-reperfusion, Post- LV: left ventricle biopsy post-reperfusion; Pre-RV: right ventricle biopsy pre-reperfusion; Post- RV: right ventricle biopsy post-reperfusion