There is significant heterogeneity and poor agreement among the criteria used to define response to cardiac resynchronization therapy across major publications, limiting the generalizability of study results.
The 26 most-cited publications on predicting response to cardiac resynchronization therapy define response using 17 different criteria. Agreement between different methods to define response to cardiac resynchronization therapy is poor 75% of the time and strong only 4% of the time, which severely limits the ability to generalize results over multiple studies.
Fornwalt et al. (2010) studied this question.
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